Structure of PDB 5fdr Chain C

Receptor sequence
>5fdrC (length=143) Species: 9606 (Homo sapiens) [Search protein sequence]
DELYRQSLEIISRYLREQATGGATSRKALETLRRVGDGVQRNHETAFQGM
LRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTI
NQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDL
3D structure
PDB5fdr Discovery of 2-Indole-acylsulfonamide Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors Using Fragment-Based Methods.
ChainC
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5X3 C H224 A227 F228 M231 M250 V253 N260 G262 R263 T266 L267 F270 H43 A46 F47 M50 M69 V72 N79 G81 R82 T85 L86 F89 BindingDB: IC50=0.940000nM,Ki=0.360000nM
Gene Ontology
Biological Process
GO:0042981 regulation of apoptotic process

View graph for
Biological Process
External links
PDB RCSB:5fdr, PDBe:5fdr, PDBj:5fdr
PDBsum5fdr
PubMed26878343
UniProtQ07820|MCL1_HUMAN Induced myeloid leukemia cell differentiation protein Mcl-1 (Gene Name=MCL1)

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