Structure of PDB 5fbn Chain C

Receptor sequence
>5fbnC (length=256) Species: 9606 (Homo sapiens) [Search protein sequence]
WEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIE
EAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQ
TQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSR
YVLDSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFT
NSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNIL
DVMDEE
3D structure
PDB5fbn Discovery of 8-Amino-imidazo[1,5-a]pyrazines as Reversible BTK Inhibitors for the Treatment of Rheumatoid Arthritis.
ChainC
Resolution1.8 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) N526 D539
Catalytic site (residue number reindexed from 1) N132 D145
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5WF C L408 V416 A428 K430 F442 M449 L460 I472 T474 M477 C481 N484 L528 S538 D539 F540 L542 L14 V22 A34 K36 F48 M55 L66 I78 T80 M83 C87 N90 L134 S144 D145 F146 L148 MOAD: ic50=0.27nM
PDBbind-CN: -logKd/Ki=9.57,IC50=0.27nM
BindingDB: IC50=8.0nM,EC50=<10.00nM
BS02 5WE C W421 Y425 S453 Y461 W27 Y31 S59 Y67
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5fbn, PDBe:5fbn, PDBj:5fbn
PDBsum5fbn
PubMed26985298
UniProtQ06187|BTK_HUMAN Tyrosine-protein kinase BTK (Gene Name=BTK)

[Back to BioLiP]