Structure of PDB 5f9f Chain C

Receptor sequence

>5f9fC (length=668) Species: 9606 (Homo sapiens) [Search protein sequence]

FKPRNYQLELALPAMKGKNTIICAPTGCGKTFVSLLICEHHLKKFPQGQK
GKVVFFANQIPVYEQQKSVFSKYFERHGYRVTGISGATAENVPVEQIVEN
NDIIILTPQILVNNLKKGTIPSLSIFTLMIFDECHNTSKQHPYNMIMFNY
LDQKLGGSSGPLPQVIGLTASVGVGDAKNTDEALDYICKLCASLDASVIA
TVKHNLEELEQVVYKPQKFFRKVESRISDKFKYIIAQLMRDTESLAKRIC
KDEFGTQKYEQWIVTVQKACMVFQMPDKDEESRICKALFLYTSHLRKYND
ALIISEHARMKDALDYLKDFFSNVRAAGFDEIEQDLTQRFEEKLQELESV
SRDPSNENPKLEDLCFILQEEYHLNPETITILFVKTRALVDALKNWIEGN
PKLSFLKPGILTGRGKTNQNTGMTLPAQKCILDAFKASGDHNILIATSVA
DEGIDIAQCNLVILYEYVGNVIKMIQTRGRGRARGSKCFLLTSNAGVIEK
EQINMYKEKMMNDSILRLQTWDEAVFREKILHIQTHEKFIRDSQPVPDKE
NKKLLCRKCKALACYTADVRVIEECHYTVLGDAFKECFVSRPHPKPKQFS
SFEKRAKIFCARQNCSHDWGIHVKYKTFEIPVIKIESFVVEDIATGVQTL
YSKWKDFHFEKIPFDPAE

3D structure

PDB

5f9f Structural basis for m7G recognition and 2'-O-methyl discrimination in capped RNAs by the innate immune receptor RIG-I.

Chain

Resolution

2.601 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

3.6.4.13: RNA helicase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	C	N298 I300 S325 G326 T347 Q349 K379 Q380 Q507 E510 K518 R546 K635 T636 R637 T662 G663 R664 T667 N668 T697 S698 N720 K750 H830 F853 K858 I875 V886 K888 W908 K909	N58 I60 S85 G86 T107 Q109 K139 Q140 Q257 E260 K268 R296 K385 T386 R387 T412 G413 R414 T417 N418 T447 S448 N470 K500 H576 F599 K604 I621 V632 K634 W654 K655	PDBbind-CN: Kd=38.5nM
BS02	ZN	C	C810 C813 C864 C869	C556 C559 C610 C615
BS03	BU3	C	K666 T667 N668 K888	K416 T417 N418 K634
BS04	BU3	C	I337 N340 N341	I97 N100 N101
BS05	BU3	C	I262 A264 C268 K270 L408 T409	I22 A24 C28 K30 L168 T169

Gene Ontology

	Molecular Function
GO:0003676	nucleic acid binding
GO:0005524	ATP binding

View graph for
Molecular Function

External links

PDB	RCSB:5f9f, PDBe:5f9f, PDBj:5f9f
PDBsum	5f9f
PubMed	26733676
UniProt	O95786\|RIGI_HUMAN Antiviral innate immune response receptor RIG-I (Gene Name=RIGI)

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