Structure of PDB 5ezv Chain C

Receptor sequence
>5ezvC (length=441) Species: 9606 (Homo sapiens) [Search protein sequence]
GRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVV
GKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKH
GRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADF
GLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALL
CGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRAT
IKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVM
NSLYSGDPQLAVAYHLIIDNRRIMNQASEFYLASSRPHPERVKAKWHLGI
RSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQ
LYLVDNRSYLLDFKSIDDEPRLGSHTMDFFEMCASLITTLA
3D structure
PDB5ezv Structural basis of allosteric and synergistic activation of AMPK by furan-2-phosphonic derivative C2 binding.
ChainC
Resolution2.99 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D139 K141 E143 N144 D157 S176
Catalytic site (residue number reindexed from 1) D131 K133 E135 N136 D149 S168
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
2.7.11.26: [tau protein] kinase.
2.7.11.31: [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 STU C L22 G23 G25 V30 A43 K45 E94 Y95 V96 E100 E143 N144 L146 D157 L14 G15 G17 V22 A35 K37 E86 Y87 V88 E92 E135 N136 L138 D149
BS02 C1V C V11 L18 G19 K29 K31 I46 D88 V3 L10 G11 K21 K23 I38 D80
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004679 AMP-activated protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5ezv, PDBe:5ezv, PDBj:5ezv
PDBsum5ezv
PubMed26952388
UniProtP54646|AAPK2_HUMAN 5'-AMP-activated protein kinase catalytic subunit alpha-2 (Gene Name=PRKAA2);
Q13131|AAPK1_HUMAN 5'-AMP-activated protein kinase catalytic subunit alpha-1 (Gene Name=PRKAA1)

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