Structure of PDB 5ez0 Chain C

Receptor sequence
>5ez0C (length=94) Species: 9606 (Homo sapiens) [Search protein sequence]
PHDNLVLIRMKPDENGRFGFNVKGGYDQKMPVIVSRVAPGTPADLCVPRL
NEGDQVVLINGRDIAEHTHDQVVLFIKASCERHSGELMLLVRPN
3D structure
PDB5ez0 Molecular Basis of the Interaction of the Human Protein Tyrosine Phosphatase Non-receptor Type 4 (PTPN4) with the Mitogen-activated Protein Kinase p38 gamma.
ChainC
Resolution2.35 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide C N525 R527 N15 R17
BS02 peptide C R527 F528 G529 F530 N531 V532 K533 Q538 K539 M540 S545 H579 D580 V583 R17 F18 G19 F20 N21 V22 K23 Q28 K29 M30 S35 H69 D70 V73
External links
PDB RCSB:5ez0, PDBe:5ez0, PDBj:5ez0
PDBsum5ez0
PubMed27246854
UniProtP29074|PTN4_HUMAN Tyrosine-protein phosphatase non-receptor type 4 (Gene Name=PTPN4)

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