Structure of PDB 5etx Chain C

Receptor sequence
>5etxC (length=193) [Search protein sequence]
KKKGSVVIVGRINLSGDTAYAQQTRGEEGCQETSQTGRDKNQVEGEVQIV
STATQTFLATSINGVLWTVYHGAGTRTIASPKGPVTQMYTNVDKDLVGWQ
APQGSRSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPISYLK
GSSGGPLLCPAGHAVGIFRTAVSTRGVAKAVDFIPVESLETTM
3D structure
PDB5etx Structural and Thermodynamic Effects of Macrocyclization in HCV NS3/4A Inhibitor MK-5172.
ChainC
Resolution2.35 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H1057 D1081 G1137 S1139
Catalytic site (residue number reindexed from 1) H71 D95 G151 S153
Enzyme Commision number 3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN C C1097 C1099 C1145 H1149 C111 C113 C159 H163
BS02 5RS C F1043 Y1056 H1057 V1078 D1081 I1132 L1135 K1136 G1137 S1139 F1154 R1155 T1156 A1157 V1158 F57 Y70 H71 V92 D95 I146 L149 K150 G151 S153 F168 R169 T170 A171 V172
Gene Ontology
Molecular Function
GO:0008233 peptidase activity
GO:0008236 serine-type peptidase activity
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
GO:0019062 virion attachment to host cell
GO:0019087 transformation of host cell by virus
GO:0046718 symbiont entry into host cell
Cellular Component
GO:0016020 membrane
GO:0033644 host cell membrane
GO:0044423 virion component

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5etx, PDBe:5etx, PDBj:5etx
PDBsum5etx
PubMed26682473
UniProtC1KIK8

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