Structure of PDB 5eg6 Chain C

Receptor sequence

>5eg6C (length=413) Species: 10090 (Mus musculus)

PPKRLTREAMRNYLKERGDQTVLILHAKVAQKSYGNEKRFFCPPPCVYLM
GSGWKKKKEQMERDGCSEQESQPCAFIGIGNSEMQQLNLEGKNYCTAKTL
YISDSDKRKHFMLSVKMFYGNSDDIGVFLSKRIKVISKPSKQSLKNADLC
IASGTKVALFNRLTVSTRYLHVEGGNFHASSQQWGAFYIHLLDDDESEGE
EFTVRDGYIHYGQTVKLVCSVTGMALPRLIIRKVDKQTALLDADDPVSQL
HKCAFYLKDTERMYLCLSQERIIQFQATPCPKEQNKEMINDGASWTIIST
DKAEYTFYEGMGPVLAPVTPVPVVESLQLNGGDVAMLELTGQNFTPNLRV
WFGDVEAETMYRCGESMLCVVPDISAFREGWRWVRQPVQVPVTLVRNDGV
IYSTSLTFTYTPE

3D structure

• PDB: 5eg6 CSL-RITA complex bound to DNA
• Chain: C
• Resolution: 2.094 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	C	K84 Y86 S191 K192	K32 Y34 S137 K138
BS02	peptide	C	N235 F236 H249 E259 E260 F261 T262 V263 D265 G282 M283 A284 L285 P286 I332 Q333 F334	N176 F177 H190 E200 E201 F202 T203 V204 D206 G223 M224 A225 L226 P227 I273 Q274 F275
BS03	dna	C	K90 R91 F92 K192 R218 T223	K38 R39 F40 K138 R162 T164

Gene Ontology

Molecular Function

• GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
• GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
• GO:0003677 DNA binding
• GO:0003700 DNA-binding transcription factor activity

Biological Process

• GO:0006355 regulation of DNA-templated transcription
• GO:0006357 regulation of transcription by RNA polymerase II

Cellular Component

• GO:0005634 nucleus

External links

• PDB: RCSB:5eg6, PDBe:5eg6, PDBj:5eg6
• PDBsum: 5eg6
• UniProt: P31266|SUH_MOUSE Recombining binding protein suppressor of hairless (Gene Name=Rbpj)