Structure of PDB 5d39 Chain C

Receptor sequence
>5d39C (length=484) Species: 9606 (Homo sapiens) [Search protein sequence]
QEELKFKTGLRRLQHRVGEIHLLREALEALAMLLQETTGELEAAKALVLK
RIQIWKRQQQLAGNGAPFEESLAPLQERCESLVDIYSQLQQEVGAAGGEL
EPKTRASLTGRLDEVLRTLVTSCFLVEKQPPQVLKTQTKFQAGVRFLLGL
RFPAKPPLVRADMVTEKQARELESTGEIINNTVPLENSIPGNCCSALFKN
LLLKKIKRCETESVTEEKCAVLFSASFTLGPGKLPIQLQALSLPLVVIVH
GNQDNNAKATILWDNAFSEMDRVPFVVAERVPWEKMCETLNLKFMAEVGT
NRGLLPEHFLFLAQKIFNDNSLSMEAFQHRSVSWSQFNKEILLGRGFTFW
QWFDGVLDLTKRCLRSYWSDRLIIGFISKQYVTSLLLNEPDGTFLLRFSD
SEIGGITIAHVIRGGSPQIENIQPFSAKDLSIRSLGDRIRDLAQLKNLYP
KKPKDEAFRSHYKPEQMGKDGRGYVPATIKMTVE
3D structure
PDB5d39 Structural basis for DNA recognition by STAT6
ChainC
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna C K284 K288 H415 K135 K139 H250 PDBbind-CN: Kd=1.8uM
BS02 dna C R370 V379 V414 H415 N417 Q418 R208 V214 V249 H250 N252 Q253 PDBbind-CN: Kd=1.8uM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0007165 signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:5d39, PDBe:5d39, PDBj:5d39
PDBsum5d39
PubMed27803324
UniProtP42226|STAT6_HUMAN Signal transducer and activator of transcription 6 (Gene Name=STAT6)

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