Structure of PDB 5cte Chain C

Receptor sequence
>5cteC (length=721) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
WLQPKRYKAHLMGTTYVYDFPELFRQASSSQWKNFSADVKLTDDFFISNE
LIEDENGELTEVEREPGANAIGMVAFKITVKTPEYPRGRQFVVVANDITF
KIGSFGPQEDEFFNKVTEYARKRGIPRIYLAANSGARIGMAEEIVPLFQV
AWNDAANPDKGFQYLYLTSEGMETLKKFDKENSVLTERTVINGEERFVIK
TIIGSEDGLGVECLRGSGLIAGATSRAYHDIFTITLVTCRSVGIGAYLVR
LGQRAIQVEGQPIILTGASALNKVLGREVYTSNLQLGGTQIMYNNGVSHL
TAVDDLAGVEKIVEWMSYVPAKRNMPVPILETKDTWDRPVDFTPTNDETY
DVRWMIEGRETESGFEYGLFDKGSFFETLSGWAKGVVVGRARLGGIPLGV
IGVETRTVENLIPADPANPNSAETLIQQAGQVWFPNSAFKTAQAINDFNN
GEQLPMMILANWRGFSGGQRDMFNEVLKYGSFIVDALVDYKQPIIIYIPP
TGELRGGSWVVVDPTINADQMEMYADVNARAGVLEPEGTVEIKFRREKLL
DTMNRLDDKYRELRSQLSNKSLAPEVHQQISKQLADRERELLPIYGQISL
QFADLHDRSSRMVAKGVISKELEWTEARRFFFWRLRRRLNEEYLIKRLSH
QVASRLEKIARIRSWYPASVDHEDDRQVATWIEENYKTLDDKLKGNAIDG
LSEVIKMLSTDDKEKLLKTLK
3D structure
PDB5cte Discovery of spirocyclic-diamine inhibitors of mammalian acetyl CoA-carboxylase.
ChainC
Resolution2.34 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 6.3.4.14: biotin carboxylase.
6.4.1.2: acetyl-CoA carboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 57L C A1761 L1762 A270 L271 PDBbind-CN: -logKd/Ki=7.80,IC50=0.016uM
BS02 57L C R1954 G1955 F1956 S1957 G1958 L2025 E2026 G2029 E2032 R463 G464 F465 S466 G467 L534 E535 G538 E541 PDBbind-CN: -logKd/Ki=7.80,IC50=0.016uM
Gene Ontology
Molecular Function
GO:0003989 acetyl-CoA carboxylase activity
GO:0016874 ligase activity

View graph for
Molecular Function
External links
PDB RCSB:5cte, PDBe:5cte, PDBj:5cte
PDBsum5cte
PubMed26411795
UniProtQ00955|ACAC_YEAST Acetyl-CoA carboxylase (Gene Name=ACC1)

[Back to BioLiP]