Structure of PDB 5ctb Chain C

Receptor sequence
>5ctbC (length=672) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
LQPKRYKAHLMGTTYVYDFPELFRQASSSQWKNFSADVKLTDDFFISNEL
IEDENGELTEVEREPGANAIGMVAFKITVKTPEYPRGRQFVVVANDITFK
IGSFGPQEDEFFNKVTEYARKRGIPRIYLAANSGARIGMAEEIVPLFQVA
WFQYLYLTSEGMETLKKFDKENSVLTERTVERFVIKTIIGSEDGLGVECL
RGSGLIAGATSRAYHDIFTITLVTCRSVGIGAYLVRLGQRAIQVEGQPII
LTGASALNKVLGREVYTSNLQLGGTQIMYNNGVSHLTAVDDLAGVEKIVE
WMSYVPAKRNMPVPILETKDTWDRPVDFTPTNDETYDVRWMIEGRETESG
FEYGLFDKGSFFETLSGWAKGVVVGRARLGGIPLGVIGVETRTVENLIPA
DPANPNSAETLIQQAGQVWFPNSAFKTAQAINDFNNGEQLPMMILANWRG
FSGGQRDMFNEVLKYGSFIVDALVDYKQPIIIYIPPTGELRGGSWVVVDP
TINADQMEMYADVNARAGVLEPEGTVEIKFRREKLLDTMNLSNKSLAPEV
HQQISKQLADRERELLPIYGQISLQFADLHDRSSRMVAKGVISKELEWTE
ARRFFFWRLRRRLNEEYLIKRLSHQASRLEKIARIRSWYPASVDHEDDRQ
VATWIEENYKTLDDKLKGLKLE
3D structure
PDB5ctb Discovery of spirocyclic-diamine inhibitors of mammalian acetyl CoA-carboxylase.
ChainC
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.3.4.14: biotin carboxylase.
6.4.1.2: acetyl-CoA carboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 57J C A1761 L1762 K1764 V1765 A256 L257 K259 V260
BS02 57J C V1923 R1954 F1956 L2025 E2026 G2029 V418 R449 F451 L520 E521 G524
Gene Ontology
Molecular Function
GO:0003989 acetyl-CoA carboxylase activity
GO:0016874 ligase activity

View graph for
Molecular Function
External links
PDB RCSB:5ctb, PDBe:5ctb, PDBj:5ctb
PDBsum5ctb
PubMed26411795
UniProtQ00955|ACAC_YEAST Acetyl-CoA carboxylase (Gene Name=ACC1)

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