Structure of PDB 5cks Chain C

Receptor sequence
>5cksC (length=343) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
NDDLRIKEIKELLPPVALLEKFPATENAANTVAHARKAIHKILKGNDDRL
LVVIGPCSIHDPVAAKEYATRLLALREELKDELEIVMRVYFEKPRTTVGW
KGLINDPHMDNSFQINDGLRIARKLLLDINDSGLPAAGEFLDMITPQYLA
DLMSWGAIGARTTESQVHRELASGLSCPVGFKNGTDGTIKVAIDAINAAG
APHCFLSVTKWGHSAIVNTSGNGDCHIILRGGKEPNYSAKHVAEVKEGLN
KAGLPAQVMIDFSHANSSKQFKKQMDVCADVCQQIAGGEKAIIGVMVESH
LVEGNQSLEPLAYGKSITDACIGWEDTDALLRQLANAVKARRG
3D structure
PDB5cks Potent Inhibition of 3-Deoxy-d-arabinoheptulosonate-7-phosphate (DAHP) Synthase by DAHP Oxime, a Phosphate Group Mimic.
ChainC
Resolution2.1181 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.5.1.54: 3-deoxy-7-phosphoheptulonate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GAL C Q170 E174 F209 L210 Q166 E170 F205 L206
BS02 52L C R92 Y94 K97 P98 R99 T100 K186 H268 D326 R88 Y90 K93 P94 R95 T96 K182 H264 D319 MOAD: Kd=3.1uM
Gene Ontology
Molecular Function
GO:0003849 3-deoxy-7-phosphoheptulonate synthase activity
GO:0016740 transferase activity
GO:0042802 identical protein binding
Biological Process
GO:0008652 amino acid biosynthetic process
GO:0009058 biosynthetic process
GO:0009073 aromatic amino acid family biosynthetic process
GO:0009423 chorismate biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5cks, PDBe:5cks, PDBj:5cks
PDBsum5cks
PubMed27933795
UniProtP0AB91|AROG_ECOLI Phospho-2-dehydro-3-deoxyheptonate aldolase, Phe-sensitive (Gene Name=aroG)

[Back to BioLiP]