Structure of PDB 5c1p Chain C

Receptor sequence
>5c1pC (length=306) Species: 632 (Yersinia pestis) [Search protein sequence]
MAEKVAVLLGGTSAEREVSLLSGQAVLAGLKEAGIDAYGVDTKDFPVTQL
KEQGFDKVFIALHGRGGEDGTLQGVLEFLQLPYTGSGVMASALTMDKLRT
KLVWQALGLPISPYVALNRQQFETLSPEELVACVAKLGLPLIVKPSHEGS
SVGMSKVDHASELQKALVEAFQHDSDVLIEKWLSGPEFTVAILGDEVLPS
IRIQPPGVFYDYDAKYLSDKTQYFCPSGLSDESEQQLAALALQAYHALDC
SGWGRVDVMQDRDGHFYLLEVNTSPGMTSHSLVPMAARQYGLSFSQLVAR
ILMLAD
3D structure
PDB5c1p Structure of D-alanine-D-alanine ligase from Yersinia pestis: nucleotide phosphate recognition by the serine loop.
ChainC
Resolution2.4 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E15 V18 L21 H63 D213 Y216 R255 D257 E270 N272 G276 H280
Catalytic site (residue number reindexed from 1) E15 V18 L21 H63 D213 Y216 R255 D257 E270 N272 G276 H280
Enzyme Commision number 6.3.2.4: D-alanine--D-alanine ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP C K97 I142 K144 E148 S151 E180 W182 L183 E187 Y210 M259 E270 K97 I142 K144 E148 S151 E180 W182 L183 E187 Y210 M259 E270
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0005524 ATP binding
GO:0008716 D-alanine-D-alanine ligase activity
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0008360 regulation of cell shape
GO:0009252 peptidoglycan biosynthetic process
GO:0071555 cell wall organization
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5c1p, PDBe:5c1p, PDBj:5c1p
PDBsum5c1p
PubMed26894530
UniProtQ8ZIE7|DDL_YERPE D-alanine--D-alanine ligase (Gene Name=ddl)

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