Structure of PDB 5bv3 Chain C

Receptor sequence
>5bv3C (length=333) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
GMFASLIKRFQFVSVLDSNPQTKVMSLLGTIDNKDAIITAEKTHFLFDET
VRDGRSTPVLYNCENEYSCINGIQELKEITSNDIYYWGLSVIKQDMESNP
TAKLNLIWPATPIHIKKYEQQNFHLVRETPEMYKRIVQPYIEEGRLKWVN
NILYEGAESERVVYKDFSEENKDDGFLILPDMKWDGMNLDSLYLVAIVYR
TDIKTIRDLRYSDRQWLINLNNKIRSIVPGCYNYAVHPDELRILVHYQPS
YYHFNIHIVNIKHPGLGNSIAAGKAILLEDIIEMLNYLGPEGYMNKTITY
AIGENHDLWKRGLEEELTKQLERDGIPKIPKIV
3D structure
PDB5bv3 An excess of catalytically required motions inhibits the scavenger decapping enzyme.
ChainC
Resolution2.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.1.59: 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 M7G C W161 E171 D194 M195 K196 H259 S263 H270 W148 E158 D181 M182 K183 H246 S250 H257 MOAD: Kd=68nM
Gene Ontology
Molecular Function
GO:0000340 RNA 7-methylguanosine cap binding
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0044692 exoribonuclease activator activity
GO:0046982 protein heterodimerization activity
GO:0140932 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity
Biological Process
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA
GO:0000956 nuclear-transcribed mRNA catabolic process
GO:0006970 response to osmotic stress
GO:0006979 response to oxidative stress
GO:0007584 response to nutrient
GO:0009267 cellular response to starvation
GO:0009408 response to heat
GO:0031086 nuclear-transcribed mRNA catabolic process, deadenylation-independent decay
GO:0110156 mRNA methylguanosine-cap decapping
Cellular Component
GO:0000932 P-body
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0048471 perinuclear region of cytoplasm
GO:0106095 m7G(5')pppN diphosphatase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5bv3, PDBe:5bv3, PDBj:5bv3
PDBsum5bv3
PubMed26258763
UniProtQ06151|DCPS_YEAST m7GpppX diphosphatase (Gene Name=DCS1)

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