Structure of PDB 5btr Chain C

Receptor sequence
>5btrC (length=322) Species: 9606 (Homo sapiens) [Search protein sequence]
DNLLFGDEIITNDWTPRPRIGPYTFVQQHLMIGTDPRTILKDLLPETIPP
PELDDMTLWQIVINILSEPPKRKKRKDINTIEDAVKLLQESKKIIVLTGY
ARLAVDFPDLPDPQAMFDIEYFRKDPRPFFKFAKEIYPGQFQPSLCHKFI
ALSDKEGKLLRNYTQNIDTLEQVAGIQRIIQCHGSFATASCLICKYKVDC
EAVRGDIFNQVVPRCAIMKPEIVFFGENLPEQFHRAMKYDKDEVDLLIVI
GSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDVELLGDCDVIINEL
CHRLGGEYAKLSFLPPNRYIFH
3D structure
PDB5btr Structural basis for allosteric, substrate-dependent stimulation of SIRT1 activity by resveratrol
ChainC
Resolution3.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N346 D348 H363
Catalytic site (residue number reindexed from 1) N166 D168 H183
Enzyme Commision number 2.3.1.-
2.3.1.286: protein acetyllysine N-acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide C F148 D150 P180 F5 D7 P18
BS02 peptide C T209 N226 F297 H363 V412 F413 F414 E416 N417 R446 P447 T47 N64 F117 H183 V223 F224 F225 E227 N228 R257 P258
BS03 STL C D292 Q294 D298 K444 D112 Q114 D118 K255 BindingDB: EC50=46200nM
BS04 STL C I223 F414 G415 I61 F225 G226 BindingDB: EC50=46200nM
BS05 STL C L206 P211 I223 N226 E230 R446 P447 L450 L44 P49 I61 N64 E68 R257 P258 L261 BindingDB: EC50=46200nM
Gene Ontology

View graph for
Molecular Function
External links
PDB RCSB:5btr, PDBe:5btr, PDBj:5btr
PDBsum5btr
PubMed26109052
UniProtQ96EB6|SIR1_HUMAN NAD-dependent protein deacetylase sirtuin-1 (Gene Name=SIRT1)

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