Structure of PDB 5bt4 Chain C

Receptor sequence
>5bt4C (length=124) Species: 9606 (Homo sapiens) [Search protein sequence]
NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLN
LPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPG
DDIVLMAEALEKLFLQKINELPTE
3D structure
PDB5bt4 Crystal structure of BRD4 first bromodomain in complex with a 3,5-dimethylisoxazol ligand
ChainC
Resolution1.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 2LO C K91 L92 N140 I146 K48 L49 N97 I103 BindingDB: Kd=8.5e+2nM,IC50=7121nM
BS02 2LO C W81 P82 Q84 Q85 W38 P39 Q41 Q42 BindingDB: Kd=8.5e+2nM,IC50=7121nM
External links
PDB RCSB:5bt4, PDBe:5bt4, PDBj:5bt4
PDBsum5bt4
PubMed
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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