Structure of PDB 5axd Chain C

Receptor sequence

>5axdC (length=430) Species: 10090 (Mus musculus)

DKLPYKVADIGLAAWGRKALDIAENEMPGLMRMREMYSASKPLKGARIAG
CLHMTVETAVLIETLVALGAEVRWSSCNIFSTQDHAAAAIAKAGIPVFAW
KGETDEEYLWCIEQTLHFKDGPLNMILDDGGDLTNLIHTKYPQLLSGIRG
ISEETTTGVHNLYKMMSNGILKVPAINVNDSVTKSKFDNLYGCRESLIDG
IKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQA
AMEGYEVTTMDEACKEGNIFVTTTGCVDIILGRHFEQMKDDAIVCNIGHF
DVEIDVKWLNENAVEKVNIKPQVDRYWLKNGRRIILLAEGRLVNLGCAMG
HPSFVMSNSFTNQVMAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKL
NVKLTKLTEKQAQYLGMPINGPFKPDHYRY

3D structure

• PDB: 5axd Crystal structure of mouse SAHH complexed with ribavirin
• Chain: C
• Resolution: 1.6 Å

Enzymatic activity

• Enzyme Commision number: 3.13.2.1: adenosylhomocysteinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	NAD	C	T157 T158 T159 N191 G222 D223 V224 T242 E243 I244 N248 T275 T276 I281 I299 G300 N346 H353	T155 T156 T157 N189 G220 D221 V222 T240 E241 I242 N246 T273 T274 I279 I297 G298 N344 H351
BS02	RBV	C	H55 T57 E59 D131 E156 T157 K186 D190 L347 H353 M358	H53 T55 E57 D129 E154 T155 K184 D188 L345 H351 M356

Gene Ontology

Molecular Function

• GO:0004013 adenosylhomocysteinase activity
• GO:0005507 copper ion binding
• GO:0005515 protein binding
• GO:0016787 hydrolase activity
• GO:0042802 identical protein binding
• GO:0051287 NAD binding

Biological Process

• GO:0006730 one-carbon metabolic process
• GO:0019510 S-adenosylhomocysteine catabolic process

Cellular Component

• GO:0005634 nucleus
• GO:0005737 cytoplasm
• GO:0005783 endoplasmic reticulum
• GO:0005829 cytosol
• GO:0042470 melanosome

External links

• PDB: RCSB:5axd, PDBe:5axd, PDBj:5axd
• PDBsum: 5axd
• UniProt: P50247|SAHH_MOUSE Adenosylhomocysteinase (Gene Name=Ahcy)