Structure of PDB 5avi Chain C

Receptor sequence
>5aviC (length=226) Species: 9606 (Homo sapiens) [Search protein sequence]
PQLSPEQLGMIEKLVAAQQRVTPWPSREARQQRFAHFTELAIVSVQEIVD
FAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITFLKDFS
YNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRP
NVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSV
HSEQVFALRLQDKKLPPLLSEIWDVH
3D structure
PDB5avi Discovery and structure-guided optimization of tert-butyl 6-(phenoxymethyl)-3-(trifluoromethyl)benzoates as liver X receptor agonists
ChainC
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide C V269 K273 R283 E284 I287 A288 K291 P437 L438 E441 V49 K53 R63 E64 I67 A68 K71 P217 L218 E221
BS02 4KM C F257 L260 A261 S264 M298 T302 F315 F326 F335 F37 L40 A41 S44 M78 T82 F95 F106 F115 BindingDB: EC50=310nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006629 lipid metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:5avi, PDBe:5avi, PDBj:5avi
PDBsum5avi
PubMed26238323
UniProtQ13133|NR1H3_HUMAN Oxysterols receptor LXR-alpha (Gene Name=NR1H3)

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