Structure of PDB 5ao1 Chain C

Receptor sequence
>5ao1C (length=457) Species: 9606 (Homo sapiens) [Search protein sequence]
MKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASHNR
FEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCHDLGHGPFS
HMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPEED
ICFIKEQIVGPLLWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFARDCH
HLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNSLHR
RAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEAYTK
LTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKIKRE
DYESLPKEVASAKPKVLLDVKLKAEDFIVDVINMDYGMQEKNPIDHVSFY
CKTAPNRAIRISQLLPEKFAEQLIRVYCKKVDRKSLYAARQYFVQWCADR
NFTKPQD
3D structure
PDB5ao1 Phospho-Dependent Regulation of Samhd1 Oligomerisation Couples Catalysis and Restriction.
ChainC
Resolution2.545 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.5.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FE C H167 H206 D207 D311 H53 H92 D93 D190
BS02 DG3 C R164 H206 D207 H215 H233 D311 Y315 H370 Y374 R50 H92 D93 H101 H119 D190 Y194 H249 Y253
BS03 DG3 C V117 I118 D137 R145 V3 I4 D23 R31
BS04 DG3 C Y155 V156 R451 Y41 V42 R330
External links
PDB RCSB:5ao1, PDBe:5ao1, PDBj:5ao1
PDBsum5ao1
PubMed26431200
UniProtQ9Y3Z3|SAMH1_HUMAN Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (Gene Name=SAMHD1)

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