Structure of PDB 5ae3 Chain C

Receptor sequence

>5ae3C (length=551) Species: 10141 (Cavia porcellus) [Search protein sequence]

PKKRQELMKWNGWGYNDSKFFLNKKGQLELTGKRYPLSGVALPTFKDWIQ
NTFGINLDHKTTSKASLNPSDTPPSIVNEDFLHELKKTNISYSQEADDRV
FRAHGHCLHEIFLLREGMFERIPDIVLWPTCHDDVVKIVNLACKYNLCII
PIGGGTSVSYGLMCPADETRTIISLDTSQMNRILWVDENNLTAHVEAGIT
GQELERQLKESGYCTGHEPDSLEFSTVGGWISTRASGMKKNIYGNIEDLV
VHMKVVTPRGVIEKSCQGPRMSTGPDIHHFIMGSEGTLGVITEATIKIRP
TPEYQKYGSVAFPNFEQGVACLREIAKQRCAPASIRLMDNQQFQFGHALG
FDPNQLSVATLLFEGDREKVLQHEKQVYDIAAKFGGLAAGEDNGQRGYLL
TYVIAYMRDLGLEYYIIGESFETSAPWDRVVDLCRNVKERIRRECKEKGV
QFPPLSTCRVTQTYDAGACIYFYFAFNYRGISDPLAVFEQTEAAAREEIL
ANGGSLSHHHGVGKLRKQWLKESISDVGFGMLKSVKDYVDPTNIFGNRNL
L

3D structure

PDB

5ae3 Discovery of Inhibitors for the Ether Lipid-Generating Enzyme Agps as Anti-Cancer Agents.

Chain

Resolution

2.18 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.5.1.26: alkylglycerone-phosphate synthase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	AWB	C	W131 F136 M421 Q425 F428 G504 Y505 L507 I511 M514 G518 I523 E526 R566 Y580	W48 F53 M338 Q342 F345 G397 Y398 L400 I404 M407 G411 I416 E419 R459 Y473
BS02	FAD	C	P234 I235 G236 G237 G238 T239 S240 V241 P302 D303 S304 S308 T309 G312 W313 S315 T316 A318 S319 E368 V373 I374 H616	P151 I152 G153 G154 G155 T156 S157 V158 P219 D220 S221 S225 T226 G229 W230 S232 T233 A235 S236 E285 V290 I291 H509

Gene Ontology

	Molecular Function
GO:0003824	catalytic activity
GO:0008609	alkylglycerone-phosphate synthase activity
GO:0016740	transferase activity
GO:0050660	flavin adenine dinucleotide binding
GO:0071949	FAD binding

	Biological Process
GO:0006629	lipid metabolic process
GO:0008610	lipid biosynthetic process
GO:0008611	ether lipid biosynthetic process

	Cellular Component
GO:0005777	peroxisome
GO:0005778	peroxisomal membrane
GO:0016020	membrane

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:5ae3, PDBe:5ae3, PDBj:5ae3
PDBsum	5ae3
PubMed	26322624
UniProt	P97275\|ADAS_CAVPO Alkyldihydroxyacetonephosphate synthase, peroxisomal (Gene Name=AGPS)

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