Structure of PDB 5acb Chain C

Receptor sequence
>5acbC (length=325) Species: 9606 (Homo sapiens) [Search protein sequence]
ESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKE
GFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEY
MDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNI
LLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTP
AIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIK
LPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTL
QSDFLKDVELSKMAPPDLPHWQDCH
3D structure
PDB5acb Covalent Targeting of Remote Cysteine Residues to Develop Cdk12 and Cdk13 Inhibitors.
ChainC
Resolution2.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D859 K861 S863 N864 D877 S889 T898
Catalytic site (residue number reindexed from 1) D144 K146 S148 N149 D162 S174 T183
Enzyme Commision number 2.7.11.22: cyclin-dependent kinase.
2.7.11.23: [RNA-polymerase]-subunit kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5I1 C I733 V741 A754 K756 F813 M816 D819 L866 Q1037 C1039 I18 V26 A39 K41 F98 M101 D104 L151 Q322 C324 PDBbind-CN: -logKd/Ki=6.80,IC50=158nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5acb, PDBe:5acb, PDBj:5acb
PDBsum5acb
PubMed27571479
UniProtQ9NYV4|CDK12_HUMAN Cyclin-dependent kinase 12 (Gene Name=CDK12)

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