Structure of PDB 4zwg Chain C

Receptor sequence

>4zwgC (length=466) Species: 9606 (Homo sapiens)

DTMKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASH
NRFEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCRNLGHGP
FSHMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPE
EDICFIKEQIVGPLLWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFARD
CHHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNSL
HRRAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEAY
TKLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKIK
REDYESLPKEVASAKPDVKLKAEDFIVDVINMDYGMQEKNPIDHVSFYCK
TAPNRAIRITKNQVSQLLPEKFAEQLIRVYCKKVDRKSLYAARQYFVQWC
ADRNFTKPQDGDVIAP

3D structure

• PDB: 4zwg Impaired dNTPase Activity of SAMHD1 by Phosphomimetic Mutation of Thr-592.
• Chain: C
• Resolution: 2.3 Å

Enzymatic activity

• Enzyme Commision number: 3.1.5.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	DTP	C	V156 F157 R372 H376 K377	V44 F45 R253 H257 K258
BS02	GTP	C	Y155 V156 V378 R451 K455	Y43 V44 V259 R332 K336
BS03	DTP	C	R333 R352 K354 N358 K523	R214 R233 K235 N239 K400
BS04	GTP	C	K116 V117 I118 D137 Q142 R145	K4 V5 I6 D25 Q30 R33
BS05	DTP	C	R164 R206 H210 H215 H233 D311 K312 Y315 R366 Y374 Q375	R52 R94 H98 H103 H121 D192 K193 Y196 R247 Y255 Q256
BS06	DTP	C	V117 N119	V5 N7

External links

• PDB: RCSB:4zwg, PDBe:4zwg, PDBj:4zwg
• PDBsum: 4zwg
• PubMed: 26294762
• UniProt: Q9Y3Z3|SAMH1_HUMAN Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (Gene Name=SAMHD1)