Structure of PDB 4ztl Chain C

Receptor sequence
>4ztlC (length=285) Species: 9606 (Homo sapiens) [Search protein sequence]
RFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVK
KLITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDLCLVYVYMPNGSLL
DRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDE
AFTAKISDFGLARASETVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGV
VLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTS
VEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
3D structure
PDB4ztl Discovery and Structure Enabled Synthesis of 2,6-Diaminopyrimidin-4-one IRAK4 Inhibitors.
ChainC
Resolution2.39 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D311 K313 A315 N316 D329 T351
Catalytic site (residue number reindexed from 1) D140 K142 A144 N145 D158 T176
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 4S1 C M192 Y262 M265 P266 G268 A315 L318 S328 D329 M29 Y91 M94 P95 G97 A144 L147 S157 D158 MOAD: ic50=1.2uM
BindingDB: IC50=1193000nM
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007165 signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:4ztl, PDBe:4ztl, PDBj:4ztl
PDBsum4ztl
PubMed26288698
UniProtQ9NWZ3|IRAK4_HUMAN Interleukin-1 receptor-associated kinase 4 (Gene Name=IRAK4)

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