Structure of PDB 4zrk Chain C

Receptor sequence
>4zrkC (length=295) Species: 10090 (Mus musculus) [Search protein sequence]
PKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYTI
KDTVAWLKMDKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLF
FLQVKKQILDEKVYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEEL
LPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYG
VNYFTIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSD
KEFTIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKA
3D structure
PDB4zrk Angiomotin binding-induced activation of Merlin/NF2 in the Hippo pathway
ChainC
Resolution2.316 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide C F35 N36 W41 D45 L49 R52 T53 F17 N18 W23 D27 L31 R34 T35
BS02 peptide C E136 A137 L140 Y144 L176 Y177 Q178 M179 W191 E194 E206 E118 A119 L122 Y126 L158 Y159 Q160 M161 W173 E176 E188
Gene Ontology
Molecular Function
GO:0003779 actin binding
GO:0008092 cytoskeletal protein binding
Cellular Component
GO:0005856 cytoskeleton

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Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:4zrk, PDBe:4zrk, PDBj:4zrk
PDBsum4zrk
PubMed26045165
UniProtP46662|MERL_MOUSE Merlin (Gene Name=Nf2)

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