Structure of PDB 4zom Chain C

Receptor sequence
>4zomC (length=219) Species: 9606 (Homo sapiens) [Search protein sequence]
TEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMW
ERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCR
AYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEI
ALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLP
PKGKLRSLCSQHVERLQIF
3D structure
PDB4zom Discovery of novel pyrazole-containing benzamides as potent ROR gamma inverse agonists.
ChainC
Resolution2.27 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 4Q3 C W317 C320 H323 F378 E379 F388 C393 L396 I397 I400 F401 H479 W50 C53 H56 F111 E112 F121 C126 L129 I130 I133 F134 H212 MOAD: ic50=3nM
BindingDB: EC50=10.0nM,IC50=4.9nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4zom, PDBe:4zom, PDBj:4zom
PDBsum4zom
PubMed26048789
UniProtP51449|RORG_HUMAN Nuclear receptor ROR-gamma (Gene Name=RORC)

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