Structure of PDB 4zjr Chain C

Receptor sequence
>4zjrC (length=220) Species: 9606 (Homo sapiens) [Search protein sequence]
SASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSM
WEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLV
RMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFS
EDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSIL
AKLPPKGKLRSLCSQHVERL
3D structure
PDB4zjr Discovery of biaryl carboxylamides as potent ROR gamma inverse agonists.
ChainC
Resolution2.702 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 4P3 C C320 H323 E379 F388 L391 C393 L396 I397 I400 F401 H479 C57 H60 E116 F125 L128 C130 L133 I134 I137 F138 H216 BindingDB: EC50=93nM,IC50=11nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4zjr, PDBe:4zjr, PDBj:4zjr
PDBsum4zjr
PubMed26048806
UniProtP51449|RORG_HUMAN Nuclear receptor ROR-gamma (Gene Name=RORC)

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