Structure of PDB 4yv1 Chain C

Receptor sequence
>4yv1C (length=275) Species: 353153 (Trypanosoma cruzi strain CL Brener) [Search protein sequence]
SGGWFREENDQWPGQAMSLRVEKVLYDAPTKFQHLTIFESDPKGPWGTVM
ALDGCIQVTDYDEFVYHEVLGHTSLCSHPKPERVLIIGGGDGGVLREVLR
HGTVEHCDLVDIDGEVMEQSKQHFPQISRSLADPRATVRVGDGLAFVRQT
PDNTYDVVIIDTTAFYKDVLRILKPDGICCNQGESIWLDLELIEKMSRFI
RETGFASVQYALMHVPTYPCGSIGTLVCSKKAGVDVTKPLRPVEDMPFAK
DLKYYDSEMHKASFALPRFARHINN
3D structure
PDB4yv1 Structural insights into the novel inhibition mechanism of Trypanosoma cruzi spermidine synthase
ChainC
Resolution1.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.16: spermidine synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 S4M C Q40 L59 Q64 Y73 H74 G95 D98 D118 I119 G150 D168 T169 T170 Q33 L52 Q57 Y66 H67 G88 D91 D111 I112 G143 D161 T162 T163
BS02 4K2 C M24 W53 M17 W46
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004766 spermidine synthase activity
GO:0016740 transferase activity
Biological Process
GO:0006596 polyamine biosynthetic process

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4yv1, PDBe:4yv1, PDBj:4yv1
PDBsum4yv1
PubMed26327378
UniProtQ4DA73

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