Structure of PDB 4yv0 Chain C

Receptor sequence
>4yv0C (length=273) Species: 353153 (Trypanosoma cruzi strain CL Brener) [Search protein sequence]
ISGGWFREEPGQAMSLRVEKVLYDAPTKFQHLTIFESDPKGPWGTVMALD
GCIQVTDYDEFVYHEVLGHTSLCSHPKPERVLIIGGGDGGVLREVLRHGT
VEHCDLVDIDGEVMEQSKQHFPQISRSLADPRATVRVGDGLAFVRQTPDN
TYDVVIIDTTEAFYKDVLRILKPDGICCNQGESIWLDLELIEKMSRFIRE
TGFASVQYALMHVPTYPCGSIGTLVCSKKAGVDVTKPLRPVEDMPFAKDL
KYYDSEMHKASFALPRFARHINN
3D structure
PDB4yv0 Structural insights into the novel inhibition mechanism of Trypanosoma cruzi spermidine synthase
ChainC
Resolution1.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.16: spermidine synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 S4M C Q40 Q64 Y73 H74 G95 D98 D118 I119 G150 D168 T169 T170 Q30 Q54 Y63 H64 G85 D88 D108 I109 G140 D158 T159 T160
BS02 4JW C M24 L26 P235 T236 M14 L16 P214 T215
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004766 spermidine synthase activity
GO:0016740 transferase activity
Biological Process
GO:0006596 polyamine biosynthetic process

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4yv0, PDBe:4yv0, PDBj:4yv0
PDBsum4yv0
PubMed26327378
UniProtQ4DA73

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