Structure of PDB 4yuz Chain C

Receptor sequence
>4yuzC (length=274) Species: 353153 (Trypanosoma cruzi strain CL Brener) [Search protein sequence]
ISGGWFREENDPGQAMSLRVEKVLYDAPTKFQHLTIFESDPKGPWGTVMA
LDGCIQVTDYDEFVYHEVLGHTSLCSHPKPERVLIIGGGDGGVLREVLRH
GTVEHCDLVDIDGEVMEQSKQHFPQISRSLADPRATVRVGDGLAFVRQTP
DNTYDVVIIDTTAFYKDVLRILKPDGICCNQGESIWLDLELIEKMSRFIR
ETGFASVQYALMHVPTYPCGSIGTLVCSKKAGVDVTKPLRPVEDMPFAKD
LKYYDSEMHKASFALPRFARHINN
3D structure
PDB4yuz Structural insights into the novel inhibition mechanism of Trypanosoma cruzi spermidine synthase.
ChainC
Resolution1.97 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.16: spermidine synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 S4M C Q40 L59 Q64 Y73 H74 G95 D98 D118 I119 G150 D168 T169 T170 Q32 L51 Q56 Y65 H66 G87 D90 D110 I111 G142 D160 T161 T162
BS02 4JV C E14 Q22 P238 C239 E8 Q14 P218 C219
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004766 spermidine synthase activity
GO:0016740 transferase activity
Biological Process
GO:0006596 polyamine biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4yuz, PDBe:4yuz, PDBj:4yuz
PDBsum4yuz
PubMed26327378
UniProtQ4DA73

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