Structure of PDB 4yb4 Chain C

Receptor sequence
>4yb4C (length=333) Species: 262724 (Thermus thermophilus HB27) [Search protein sequence]
AYRICLIEGDGIGHEVIPAARRVLEATGLPLEFVEAEAGWETFERRGTSV
PEETVEKILSCHATLFGAATSPTRKVPGFFGAIRYLRRRLDLYANVRPAK
SRPVPGSRPGVDLVIVRENTEGLYVEQERRYLDVAIADAVISKKASERIG
RAALRIAEGRPRKTLHIAHKANVLPLTQGLFLDTVKEVAKDFPLVNVQDI
IVDNCAMQLVMRPERFDVIVTTNLLGDILSDLAAGLVGGLGLAPSGNIGD
TTAVFEPVHGSAPDIAGKGIANPTAAILSAAMMLDYLGEKEAAKRVEKAV
DLVLERGPRTPDLGGDATTEAFTEAVVEALKSL
3D structure
PDB4yb4 Structure of homoisocitrate dehydrogenase from Thermus thermophilus in complex with homoisocitrate, magnesium(II) and NADH
ChainC
Resolution2.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y125 K171 D204 D228 D232
Catalytic site (residue number reindexed from 1) Y124 K170 D203 D227 D231
Enzyme Commision number 1.1.1.286: isocitrate--homoisocitrate dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 48Y C S72 R85 R88 R98 R118 Y125 D228 S71 R84 R87 R97 R117 Y124 D227
BS02 NAI C A70 T71 S72 L241 G242 E257 H260 G261 S262 A263 D265 I266 N273 A69 T70 S71 L240 G241 E256 H259 G260 S261 A262 D264 I265 N272
BS03 48Y C K171 N173 K170 N172
Gene Ontology
Molecular Function
GO:0004449 isocitrate dehydrogenase (NAD+) activity
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
GO:0047046 homoisocitrate dehydrogenase activity
Biological Process
GO:0006099 tricarboxylic acid cycle
GO:0006102 isocitrate metabolic process
GO:0009085 lysine biosynthetic process
GO:0019878 lysine biosynthetic process via aminoadipic acid

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Molecular Function
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Biological Process
External links
PDB RCSB:4yb4, PDBe:4yb4, PDBj:4yb4
PDBsum4yb4
PubMed
UniProtQ72IW9|HICDH_THET2 Isocitrate/homoisocitrate dehydrogenase (Gene Name=hicd)

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