Structure of PDB 4y95 Chain C

Receptor sequence
>4y95C (length=266) Species: 9913 (Bos taurus) [Search protein sequence]
AWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFI
EEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRF
QTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGMT
RFVLDDEYTSSTGTKFPVKWASPEVLMYSKFSSKSDIWAFGVLMWEIYSL
GKMPYERFTNSETAEHIAQGLRLPRPHLASERVYAIMYSCWHEKADERPT
FKILLSNILDVMDEES
3D structure
PDB4y95 Autoinhibition of Bruton's tyrosine kinase (Btk) and activation by soluble inositol hexakisphosphate.
ChainC
Resolution1.599 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D521 A523 R525 N526 D539 T557
Catalytic site (residue number reindexed from 1) D128 A130 R132 N133 D146 T164
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 746 C L408 F413 V416 A428 K430 Y476 M477 A478 G480 N526 L528 D539 L15 F20 V23 A35 K37 Y83 M84 A85 G87 N133 L135 D146
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4y95, PDBe:4y95, PDBj:4y95
PDBsum4y95
PubMed25699547
UniProtQ3ZC95

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