Structure of PDB 4y83 Chain C

Receptor sequence
>4y83C (length=293) Species: 9606 (Homo sapiens) [Search protein sequence]
SSVRYGTVEDLLAFANHPQESGILLNMVITPQNGRYQIDSDVLIPWKLTY
RNIGSDFIPRGKVYLAQDIKTKKRMACKLIPVDQFKPSDVEIQACFRHEN
IAELYGAVLWGETVHLFMEAGEGGSVLEKLESCGPMREFEIIWVTKHVLK
GLDFLHSKKVIHHDIKPSNIVFMSTKAVLVDFGLSVQMEDVYFPKDLRGT
EIYMSPEVILCRGHSTKADIYSLGATLIHMQTGTPPWVKRYPYPSYLYII
HKQAPPLEDICSPGMRELIEASLERNPNHRPRAADLLKHEALN
3D structure
PDB4y83 The Crystal Structure of Cancer Osaka Thyroid Kinase Reveals an Unexpected Kinase Domain Fold.
ChainC
Resolution2.89 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D253 K255 N258 D270 T290
Catalytic site (residue number reindexed from 1) D164 K166 N169 D181 T200
Enzyme Commision number 2.7.11.25: mitogen-activated protein kinase kinase kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 49B C W132 I144 R146 V152 A165 M207 E208 G210 G213 V269 D270 W46 I58 R60 V63 A76 M118 E119 G121 G124 V180 D181
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4y83, PDBe:4y83, PDBj:4y83
PDBsum4y83
PubMed25918157
UniProtP41279|M3K8_HUMAN Mitogen-activated protein kinase kinase kinase 8 (Gene Name=MAP3K8)

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