Structure of PDB 4xif Chain C

Receptor sequence
>4xifC (length=702) Species: 9606 (Homo sapiens) [Search protein sequence]
SCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVL
QQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQCYTRA
IQINPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPDFPDAYCNLAH
CLQIVCDWTDYDERMKKLVSIVADQLEKNRLPSVHPHHSMLYPLSHGFRK
AIAERHGNLCLDKINVLHKPPYEHPKDLKLSDGRLRVGYVSSDFGNHPTS
HLMQSIPGMHNPDKFEVFCYALSPDDGTNFRVKVMAEANHFIDLSQIPCN
GKAADRIHQDGIHILVNMNGYTKGARNELFALRPAPIQAMWLGYPGTSGA
LFMDYIITDQETSPAEVAEQYSEKLAYMPHTFFIGDHANMFPHLKKKAVI
DFKHIYDNRIVLNGIDLKAFLDSLPDVKIVKMKCALNMPVIPMNTIAEAV
IEMINRGQIQITINGFSISNGLATTQINNKAATGEEVPRTIIVTTRSQYG
LPEDAIVYCNFNQLYKIDPSTLQMWANILKRVPNSVLWLLRFPAVGEPNI
QQYAQNMGLPQNRIIFSPVAPKEEHVRRGQLADVCLDTPLCNGHTTGMDV
LWAGTPMVTMPGETLASRVAASQLTCLGCLELIAKNRQEYEDIAVKLGTD
LEYLKKVRGKVWKQRISSPLFNTKQYTMELERLYLQMWEHYAAGNKPDHM
IK
3D structure
PDB4xif The active site of O-GlcNAc transferase imposes constraints on substrate sequence.
ChainC
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.1.255: protein O-GlcNAc transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide C N557 P559 T633 K634 Q839 P897 N246 P248 T322 K323 Q513 P571
BS02 12V C H498 P559 T560 G654 P656 Q839 K842 V895 A896 K898 H901 H920 T921 D925 H187 P248 T249 G343 P345 Q513 K516 V569 A570 K572 H575 H594 T595 D599
External links
PDB RCSB:4xif, PDBe:4xif, PDBj:4xif
PDBsum4xif
PubMed26237509
UniProtO15294|OGT1_HUMAN UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (Gene Name=OGT)

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