Structure of PDB 4xi3 Chain C

Receptor sequence
>4xi3C (length=236) Species: 9606 (Homo sapiens) [Search protein sequence]
LALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELV
HMINWAKRVPGFVDLTSHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFA
PNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLN
SGVYTTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLL
ILSHIRHMSNKGMEHLYSMKCKNVVPSYDLLLEMLD
3D structure
PDB4xi3 Biochemical and Structural Basis for Constitutive Activity and Reduced SERM Potency in Acquired SERM/AI Resistant Metastatic Breast Cancers via ESR1 Somatic Mutation
ChainC
Resolution2.491 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 29S C L346 T347 A350 D351 E353 L354 W383 M388 R394 F404 I424 H524 V533 P535 L41 T42 A45 D46 E48 L49 W78 M83 R89 F99 I119 H215 V224 P226 BindingDB: IC50=50nM
External links
PDB RCSB:4xi3, PDBe:4xi3, PDBj:4xi3
PDBsum4xi3
PubMed30489256
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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