Structure of PDB 4xg8 Chain C

Receptor sequence
>4xg8C (length=254) Species: 9606 (Homo sapiens) [Search protein sequence]
YLDRKLLTLEDKELGSGGTVKKGYYQMKKVVKTVAVKILKPALKDELLAE
ANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKN
IIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALR
ADENYYKAQPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRG
MKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELR
LRNY
3D structure
PDB4xg8 Crystal structures of spleen tyrosine kinase in complex with novel inhibitors: structural insights for design of anticancer drugs
ChainC
Resolution2.4 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N499 D512
Catalytic site (residue number reindexed from 1) N129 D142
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 X8G C L377 G378 V385 A400 M448 M450 A451 G454 P455 R498 L501 D512 L14 G15 V20 A35 M78 M80 A81 G84 P85 R128 L131 D142 MOAD: ic50=1.9nM
BindingDB: IC50=11.1nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4xg8, PDBe:4xg8, PDBj:4xg8
PDBsum4xg8
PubMed27504936
UniProtP43405|KSYK_HUMAN Tyrosine-protein kinase SYK (Gene Name=SYK)

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