Structure of PDB 4xdk Chain C

Receptor sequence
>4xdkC (length=233) Species: 9606 (Homo sapiens) [Search protein sequence]
KWKTVVAIFVVVVVYLVTGGLVFRALEQPFESSQKNTIALEKAEFLRDHV
CVSPQELETLIQHALDADNAGVSPIHWDLGSAFFFAGTVITTIGYGNIAP
STEGGKIFCILYAIFGIPLFGFLLAGIGDQLGTIFGKSIARVEKVFRKKR
VISTILFILAGCIVFVTIPAVIFKYIEGWTALESIYFVVVTLTTVGFGDF
VAGPLVWFWILVGLAYFAAVLSMIGDWLRVLSK
3D structure
PDB4xdk K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac.
ChainC
Resolution3.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 K C I173 G174 Y175 V282 G283 F284 I93 G94 Y95 V195 G196 F197
BS02 K C T172 I173 T281 V282 G283 T92 I93 T194 V195 G196
BS03 K C T172 T281 T92 T194
BS04 408 C V253 L279 T280 F316 V166 L192 T193 F217
BS05 405 C V253 L279 T280 F316 V166 L192 T193 F217
BS06 408 C I194 I197 P198 I114 I117 P118
BS07 405 C I194 P198 I114 P118
Gene Ontology
Molecular Function
GO:0005267 potassium channel activity
Biological Process
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:4xdk, PDBe:4xdk, PDBj:4xdk
PDBsum4xdk
PubMed25766236
UniProtP57789|KCNKA_HUMAN Potassium channel subfamily K member 10 (Gene Name=KCNK10)

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