Structure of PDB 4wyo Chain C

Receptor sequence
>4wyoC (length=723) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
WLQPKRYKAHLMGTTYVYDFPELFRQASSSQWKNFSADVKLTDDFFISNE
LIEDENGELTEVEREPGANAIGMVAFKITVKTPEYPRGRQFVVVANDITF
KIGSFGPQEDEFFNKVTEYARKRGIPRIYLAANSGARIGMAEEIVPLFQV
AWNDAANPDKGFQYLYLTSEGMETLKKFDKENSVLTERTVINGEERFVIK
TIIGSEDGLGVECLRGSGLIAGATSRAYHDIFTITLVTCRSVGIGAYLVR
LGQRAIQVEGQPIILTGASALNKVLGREVYTSNLQLGGTQIMYNNGVSHL
TAVDDLAGVEKIVEWMSYVPAKRNMPVPILETKDTWDRPVDFTPTNDETY
DVRWMIEGRETESGFEYGLFDKGSFFETLSGWAKGVVVGRARLGGIPLGV
IGVETRTVENLIPADPANPNSAETLIQQAGQVWFPNSAFKTAQAINDFNN
GEQLPMMILANWRGFSGGQRDMFNEVLKYGSFIVDALVDYKQPIIIYIPP
TGELRGGSWVVVDPTINADQMEMYADVNARAGVLEPEGTVEIKFRREKLL
DTMNRLDDKYRELRSQLSNKSLAPEVHQQISKQLADRERELLPIYGQISL
QFADLHDRSSRMVAKGVISKELEWTEARRFFFWRLRRRLNEEYLIKRLSH
QVGEASRLEKIARIRSWYPASVDHEDDRQVATWIEENYKTLDDKLKGNAI
DGLSEVIKMLSTDDKEKLLKTLK
3D structure
PDB4wyo Decreasing the Rate of Metabolic Ketone Reduction in the Discovery of a Clinical Acetyl-CoA Carboxylase Inhibitor for the Treatment of Diabetes.
ChainC
Resolution2.89 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.3.4.14: biotin carboxylase.
6.4.1.2: acetyl-CoA carboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3W2 C A1761 L1762 V1765 A270 L271 V274 PDBbind-CN: -logKd/Ki=6.95,IC50=111nM
BS02 3W2 C V1923 R1954 F1956 G1958 L2025 E2026 G2029 E2032 V432 R463 F465 G467 L534 E535 G538 E541 PDBbind-CN: -logKd/Ki=6.95,IC50=111nM
Gene Ontology
Molecular Function
GO:0003989 acetyl-CoA carboxylase activity
GO:0016874 ligase activity

View graph for
Molecular Function
External links
PDB RCSB:4wyo, PDBe:4wyo, PDBj:4wyo
PDBsum4wyo
PubMed25423286
UniProtQ00955|ACAC_YEAST Acetyl-CoA carboxylase (Gene Name=ACC1)

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