Structure of PDB 4wop Chain C

Receptor sequence
>4wopC (length=225) Species: 419947 (Mycobacterium tuberculosis H37Ra) [Search protein sequence]
ATILVVTGTGTGVGKTVVCAALASAARQAGIDVAVCKPVQTGTARGDDDL
AEVGRLAGVTQLAGLARYPQPMAPAAAAEHAGMALPARDQIVRLIADLDR
PGRLTLVEGAGGLLVELAEPGVTLRDVAVDVAAAALVVVTADLGTLNHTK
LTLEALAAQQVSCAGLVIGSWPDPPGLVAASNRSALARIAMVRAALPAGA
ASLDAGDFAAMSAAAFDRNWVAGLV
3D structure
PDB4wop Nucleotide triphosphate promiscuity in Mycobacterium tuberculosis dethiobiotin synthetase.
ChainC
Resolution2.393 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) T11 G12 K15 T16 K37 T41 G54 E108
Catalytic site (residue number reindexed from 1) T11 G12 K15 T16 K37 T41 G54 E108
Enzyme Commision number 6.3.3.3: dethiobiotin synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CTP C G12 G14 K15 T16 V17 D49 E108 G169 P197 G199 A200 A201 G12 G14 K15 T16 V17 D49 E108 G169 P197 G199 A200 A201 MOAD: Kd=17.2uM
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004141 dethiobiotin synthase activity
GO:0005524 ATP binding
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0009102 biotin biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4wop, PDBe:4wop, PDBj:4wop
PDBsum4wop
PubMed25801336
UniProtP9WPQ5|BIOD_MYCTU Dethiobiotin synthetase BioD (Gene Name=bioD)

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