Structure of PDB 4w9j Chain C

Receptor sequence
>4w9jC (length=141) Species: 9606 (Homo sapiens) [Search protein sequence]
VLRSVNSREPSQVIFCNRSPRVVLPVWLNFDGEPQPYPTLPPGTGRRIHS
YRGHLWLFRDAGTHDGLLVNQTELFVPSLNVDGQPIFANITLPVYTLKER
CLQVVRSLVKPENYRRLDIVRSLYEDLEDHPNVQKDLERLT
3D structure
PDB4w9j Structure-Guided Design and Optimization of Small Molecules Targeting the Protein-Protein Interaction between the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities.
ChainC
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3JH C N67 W88 F91 Y98 I109 H110 S111 Y112 H115 W117 N6 W27 F30 Y37 I48 H49 S50 Y51 H54 W56 MOAD: Kd=0.588uM
PDBbind-CN: -logKd/Ki=6.23,Kd=0.588uM
BindingDB: Kd=588nM
External links
PDB RCSB:4w9j, PDBe:4w9j, PDBj:4w9j
PDBsum4w9j
PubMed25166285
UniProtP40337|VHL_HUMAN von Hippel-Lindau disease tumor suppressor (Gene Name=VHL)

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