Structure of PDB 4w9d Chain C

Receptor sequence

>4w9dC (length=141) Species: 9606 (Homo sapiens) [Search protein sequence]

VLRSVNSREPSQVIFCNRSPRVVLPVWLNFDGEPQPYPTLPPGTGRRIHS
YRGHLWLFRDAGTHDGLLVNQTELFVPSLNVDGQPIFANITLPVYTLKER
CLQVVRSLVKPENYRRLDIVRSLYEDLEDHPNVQKDLERLT

3D structure

PDB

4w9d Structure-Guided Design and Optimization of Small Molecules Targeting the Protein-Protein Interaction between the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities.

Chain

Resolution

2.2 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	3JK	C	W88 Y98 I109 H110 S111 Y112 H115 W117	W27 Y37 I48 H49 S50 Y51 H54 W56	MOAD: Kd=10.2uM PDBbind-CN: -logKd/Ki=4.99,Kd=10.2uM BindingDB: Kd=10200nM

External links

PDB	RCSB:4w9d, PDBe:4w9d, PDBj:4w9d
PDBsum	4w9d
PubMed	25166285
UniProt	P40337\|VHL_HUMAN von Hippel-Lindau disease tumor suppressor (Gene Name=VHL)

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