Structure of PDB 4ump Chain C

Receptor sequence
>4umpC (length=311) Species: 9606 (Homo sapiens) [Search protein sequence]
MKDYDELLKYYELHETIGTAKVKLACHILTGEMVAIKIMDKNSDLPRIKT
EIEALKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSE
EETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAK
GALAYAAPELIQGKGSEADVWSMGILLYVLMCGFLPFDDDTAAALVAKIM
RGKYDVPKWLSPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQDYNYPVE
WQSKNPFIHLDDDCVTELSVHHRNNRQTMEDLISLWQYDHLTATYLLLLA
KKARGKPVRLR
3D structure
PDB4ump Fragment-Based Discovery of Type I Inhibitors of Maternal Embryonic Leucine Zipper Kinase
ChainC
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D132 K134 E136 N137 D150 A171
Catalytic site (residue number reindexed from 1) D126 K128 E130 N131 D144 A152
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5QM C I17 V25 E57 L86 C89 L139 I149 I17 V22 E51 L80 C83 L133 I143 BindingDB: IC50=3100nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4ump, PDBe:4ump, PDBj:4ump
PDBsum4ump
PubMed25589925
UniProtQ14680|MELK_HUMAN Maternal embryonic leucine zipper kinase (Gene Name=MELK)

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