Structure of PDB 4um9 Chain C

Receptor sequence
>4um9C (length=589) Species: 9606 (Homo sapiens) [Search protein sequence]
FNLDVDSPAEYSGPEGSYFGFAVDFFVPSRMFLLVGAPKANTTQPGIVEG
GQVLKCDWSSTRRCQPIEFDATGNRDYAKDDPLEFKSHQWFGASVRSKQD
KILACAPLYHWRTEMKQEREPVGTCFLQDGTKTVEYAPCRSQDIDADGQG
FCQGGFSIDFTKADRVLLGGPGSFYWQGQLISDQVAEIVSKYDPNVYSIK
YNNQLATRTAQAIFDDSYLGYSVAVGDFNGDGIDDFVSGVPRAARTLGMV
YIYDGKNMSSLYNFTGEQMAAYFGFSVAATDINGDDYADVFIGAPLFMDR
GSDGKLQEVGQVSVSLQRASGDFQTTKLNGFEVFARFGSAIAPLGDLDQD
GFNDIAIAAPYGGEDKKGIVYIFNGRSTGLNAVPSQILEGQWAARSCPPS
FGYSMKGATDIDKNGYPDLIVGAFGVDRAILYRARPVITVNAGLEVYPSI
LNQDNKTCSLPGTALKVSCFNVRFCLKADGKGVLPRKLNFQVELLLDKLK
GAIRRALFLYSRSPSHSKNMTISRGGLMQCEELIAYLRDESEFRDKLTPI
TIFMEYRLDYRTAADTTGLQPILNQFTPANISRQAHILL
3D structure
PDB4um9 Structural Determinants of Integrin Beta-Subunit Specificity for Latent Tgf-Beta
ChainC
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide C F177 Y178 D218 F174 Y175 D215
BS02 CA C D415 N417 Y419 D421 D412 N414 Y416 D418
BS03 CA C D349 D351 D353 F355 D357 D346 D348 D350 F352 D354
BS04 CA C D230 N232 D234 I236 D238 D227 N229 D231 I233 D235
BS05 CA C D284 N286 D288 Y290 D292 D281 N283 D285 Y287 D289
BS06 MAN C E448 Y450 E445 Y447
Gene Ontology
Cellular Component
GO:0008305 integrin complex

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Biological Process
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Cellular Component
External links
PDB RCSB:4um9, PDBe:4um9, PDBj:4um9
PDBsum4um9
PubMed25383667
UniProtP06756|ITAV_HUMAN Integrin alpha-V (Gene Name=ITGAV)

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