Structure of PDB 4um8 Chain C

Receptor sequence
>4um8C (length=588) Species: 9606 (Homo sapiens) [Search protein sequence]
FNLDVDSPAEYSGPEGSYFGFAVDFFVPSSRMFLLVGAPKANTTQPGIVE
GGQVLKCDWSSTRRCQPIEFDATGNRDYAKDDPLEFKSHQWFGASVRSKQ
DKILACAPLYHWRTEMKQEREPVGTCFLQDGTKTVEYAPCRSQDIDADGQ
GFCQGGFSIDFTKADRVLLGGPGSFYWQGQLISDQVAEIVSKYDPNVYSI
KYNNQLATRTAQAIFDDSYLGYSVAVGDFNGDGIDDFVSGVPRAARTLGM
VYIYDGKNMSSLYNFTGEQMAAYFGFSVAATDINGDDYADVFIGAPLFMD
RGSDGKLQEVGQVSVSLQRASGDFQTTKLNGFEVFARFGSAIAPLGDLDQ
DGFNDIAIAAPYGGEDKKGIVYIFNGRSTGLNAVPSQILEGQWAARSCPP
SFGYSMKGATDIDKNGYPDLIVGAFGVDRAILYRARPVITVNAGLEVYPS
ILNQDNKTCSLPGTALKVSCFNVRFCLKADGKGVLPRKLNFQVELLLDKL
KGAIRRALFLYSRSPSHSKNMTISRGGLMQCEELIAYLRDESEFRDKLTP
ITIFMEYRLDYRTATTGLQPILNQFTPANISRQAHILL
3D structure
PDB4um8 Structural Determinants of Integrin Beta-Subunit Specificity for Latent Tgf-Beta
ChainC
Resolution2.852 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MAN C K330 L331 K328 L329
BS02 CA C D415 N417 Y419 D421 A437 D413 N415 Y417 D419 A435
BS03 CA C D349 D351 D353 F355 D357 D347 D349 D351 F353 D355
BS04 CA C D230 N232 D234 I236 D238 D228 N230 D232 I234 D236
BS05 CA C D284 N286 D288 Y290 D292 D282 N284 D286 Y288 D290
Gene Ontology
Cellular Component
GO:0008305 integrin complex

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Biological Process
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Cellular Component
External links
PDB RCSB:4um8, PDBe:4um8, PDBj:4um8
PDBsum4um8
PubMed25383667
UniProtP06756|ITAV_HUMAN Integrin alpha-V (Gene Name=ITGAV)

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