Structure of PDB 4ufv Chain C

Receptor sequence

>4ufvC (length=372) Species: 5855 (Plasmodium vivax)

MDYKFWYTQPVPKINDEFNESVNEPFISDNKVEDVRKDEYKLPPGYSWYV
CDVKDEKDRSEIYTLLTDNYVEDDDNIFRFNYSAEFLLWALTSPNYLKTW
HIGVKYDASNKLIGFISAIPTDICIHKRTIKMAEVNFLCVHKTLRSKRLA
PVLIKEITRRINLENIWQAIYTAGVYLPKPVSDARYYHRSINVKKLIEIG
FKLYRVEDTLNIKNMRLMKKKDVEGVHKLLGSYLEQFNLYAVFTKEEIAH
WFLPIENVIYTYVNEENGKIKDMISFYSLPSQILGNDKYSTLNAAYSFYN
VTTTATFKQLMQDAILLAKRNNFDVFNALEVMQNKSVFEDLKFGEGDGSL
KYYLYNWKCASFAPAHVGIVLL

3D structure

• PDB: 4ufv Discovery of Pyridyl-Based Inhibitors of Plasmodium Falciparum N-Myristoyltransferase
• Chain: C
• Resolution: 1.75 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): N161 F162 L163 T197 L410
• Catalytic site (residue number reindexed from 1): N136 F137 L138 T172 L372
• Enzyme Commision number: 2.3.1.97: glycylpeptide N-tetradecanoyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	NHW	C	Y28 K29 F30 W31 Y95 V96 N161 L163 C164 V165 R170 S171 R173 A175 I179 T183 I186 W192 A194 Y196 T197 A198 L202 Y393	Y3 K4 F5 W6 Y70 V71 N136 L138 C139 V140 R145 S146 R148 A150 I154 T158 I161 W167 A169 Y171 T172 A173 L177 Y355
BS02	31A	C	E97 D98 F103 F105 Y107 Y211 S319 Y334 L367 L410	E72 D73 F78 F80 Y82 Y186 S281 Y296 L329 L372
BS03	MG	C	L169 R170 K172 L174	L144 R145 K147 L149
BS04	GOA	C	E159 N161 L410	E134 N136 L372

Gene Ontology

Molecular Function

• GO:0004379 glycylpeptide N-tetradecanoyltransferase activity
• GO:0016746 acyltransferase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006499 N-terminal protein myristoylation
• GO:0018008 N-terminal peptidyl-glycine N-myristoylation

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:4ufv, PDBe:4ufv, PDBj:4ufv
• PDBsum: 4ufv
• PubMed: 26962430
• UniProt: A5K1A2