Structure of PDB 4u7t Chain C

Receptor sequence

>4u7tC (length=418) Species: 9606 (Homo sapiens)

EFRERLVYEVRQKCRNIEDICISCGSLNVTLEHPLFVGGMCQNCKNCFLE
CAYQYDDDGYQSYCTICCGGREVLMCGNNNCCRCFCVECVDLLVGPGAAQ
AAIKEDPWNCYMCGHKGTYGLLRRREDWPSRLQMFFAPKVYPPVPAEKRK
PIRVLSLFDGIATGLLVLKDLGIQVDRYIASEVCEDSITVGMVRHQGKIM
YVGDVRSVTQKHIQEWGPFDLVIGGSPCNDLSIVNPARKGLYEGTGRLFF
EFYRLLHDARPKEGDDRPFFWLFENVVAMGVSDKRDISRFLESNPVMIDA
KEVSAAHRARYFWGNLPGMNRPLASTVNDKLELQECLEHGRIAKFSKVRT
IQHFPVFMNEKEDILWCTEMERVFGFPVHYTDVSNMSRLARQRLLGRSWS
VPVIRHLFAPLKEYFACV

3D structure

• PDB: 4u7t Structural insight into autoinhibition and histone H3-induced activation of DNMT3A
• Chain: C
• Resolution: 2.9 Å

Enzymatic activity

• Enzyme Commision number: 2.1.1.-
  2.1.1.37: DNA (cytosine-5-)-methyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	C	D529 D531 Q534 Y536 G543 R544 E545 V546 L547 M548 A575 I576 E578 W581	D56 D58 Q61 Y63 G70 R71 E72 V73 L74 M75 A102 I103 E105 W108
BS02	ZN	C	C494 C497 C514 C517	C21 C24 C41 C44
BS03	ZN	C	C537 C540 C562	C64 C67 C89
BS04	ZN	C	C554 C583 C586	C81 C110 C113
BS05	SAH	C	F640 D641 G642 I643 T645 E664 V665 D686 V687 G707 R891 S892 W893	F158 D159 G160 I161 T163 E182 V183 D204 V205 G225 R397 S398 W399

Gene Ontology

Molecular Function

• GO:0008168 methyltransferase activity

Biological Process

• GO:0010468 regulation of gene expression

External links

• PDB: RCSB:4u7t, PDBe:4u7t, PDBj:4u7t
• PDBsum: 4u7t
• PubMed: 25383530
• UniProt: Q9Y6K1|DNM3A_HUMAN DNA (cytosine-5)-methyltransferase 3A (Gene Name=DNMT3A)