Structure of PDB 4txn Chain C

Receptor sequence
>4txnC (length=290) Species: 6183 (Schistosoma mansoni) [Search protein sequence]
IVNSHLSELDEDVFHHFGFTTKSFDFKEKFGDVKFVCVCGSSGRIHNFAI
SMAKLAGLALPVENIAGSHARFVLYKVDHILFADHGMGIPSALIMLHEVT
KLLHYAGCKDVLFIRLGTSGGLGVKPGTIVLSDRCVNTKLEPYNELCILG
KPVRRQTIVDLNTVNELKKLSENLSLECSVVVGGTIAANDFYEEQGRLDG
SICTFSKEEKLAFLQSAYEHGIRNMEMEGTAITSHCYLTGHRAILVCVTA
VNRLEGDQITISTDEFTLFAQRPGQLVGEYLKRNNGIIVR
3D structure
PDB4txn Analysis of two Schistosoma mansoni uridine phosphorylases isoforms suggests the emergence of a protein with a non-canonical function.
ChainC
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.3: uridine phosphorylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 URF C S125 G126 F197 Q201 R203 M231 M233 S119 G120 F191 Q195 R197 M225 M227
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004850 uridine phosphorylase activity
GO:0016757 glycosyltransferase activity
GO:0042802 identical protein binding
GO:0047847 deoxyuridine phosphorylase activity
Biological Process
GO:0006218 uridine catabolic process
GO:0009116 nucleoside metabolic process
GO:0009166 nucleotide catabolic process
GO:0044206 UMP salvage
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4txn, PDBe:4txn, PDBj:4txn
PDBsum4txn
PubMed26898674
UniProtG4VGI0|UPPA_SCHMA Uridine phosphorylase A (Gene Name=UPPA)

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