Structure of PDB 4tot Chain C

Receptor sequence
>4totC (length=164) Species: 10116 (Rattus norvegicus) [Search protein sequence]
QNPLVYLDVGADGQPLGRVVLELKADVVPKTAENFRALCTGEKGFGYKGS
TFHRVIPAFMCQAGDFTNHNGTGGKSIYGSRFPDENFTLKHVGPGVLSMA
NAGPNTNGSQFFICTIKTDWLDGKHVVFGHVIEGMDVVKKIESFGSKSGK
TSKKIVITDCGQLS
3D structure
PDB4tot Potent nonimmunosuppressive cyclophilin inhibitors with improved pharmaceutical properties and decreased transporter inhibition.
ChainC
Resolution2.39 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) R55 F60 Q63 N102 F113 L122 H126
Catalytic site (residue number reindexed from 1) R54 F59 Q62 N101 F112 L121 H125
Enzyme Commision number 5.2.1.8: peptidylprolyl isomerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide C R55 F60 M61 Q63 G72 T73 A101 N102 Q111 F113 W121 L122 H126 R54 F59 M60 Q62 G71 T72 A100 N101 Q110 F112 W120 L121 H125
Gene Ontology
Molecular Function
GO:0003755 peptidyl-prolyl cis-trans isomerase activity
Biological Process
GO:0000413 protein peptidyl-prolyl isomerization
GO:0006457 protein folding

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Molecular Function
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Biological Process
External links
PDB RCSB:4tot, PDBe:4tot, PDBj:4tot
PDBsum4tot
PubMed25310383
UniProtP29117|PPIF_RAT Peptidyl-prolyl cis-trans isomerase F, mitochondrial (Gene Name=Ppif)

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