Structure of PDB 4to5 Chain C

Receptor sequence

>4to5C (length=479) Species: 9606 (Homo sapiens) [Search protein sequence]

TMKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASHN
RFEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCRNLGHGPF
SHMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPEE
DICFIKEQIVGPLLWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFARDC
HHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNSLH
RRAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEAYT
KLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKIKR
EDYESLPKEVASAKPKVLLDVKLKAEDFIVDVINMDYGMQEKNPIDHVSF
YCKTAPNRAIRITKNQVSQLLPEKFAEQLIRVYCKKVDRKSLYAARQYFV
QWCADRNFTKPQDGDVIAPLITPQKKEWN

3D structure

PDB

4to5 Structural basis of cellular dNTP regulation by SAMHD1.

Chain

Resolution

2.8 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

3.1.5.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	TTP	C	V156 F157 R372 H376 K377	V43 F44 R252 H256 K257
BS02	TTP	C	R333 R352 K354 K523	R213 R232 K234 K403
BS03	DCP	C	R164 R206 H210 H215 H233 D311 K312 Y315 R366 Y374	R51 R93 H97 H102 H120 D191 K192 Y195 R246 Y254
BS04	TTP	C	N119 H125	N6 H12
BS05	GTP	C	Y155 V156 V378 R451 K455	Y42 V43 V258 R331 K335
BS06	GTP	C	K116 V117 I118 D137 R145	K3 V4 I5 D24 R32

External links

PDB	RCSB:4to5, PDBe:4to5, PDBj:4to5
PDBsum	4to5
PubMed	25267621
UniProt	Q9Y3Z3\|SAMH1_HUMAN Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (Gene Name=SAMHD1)

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