Structure of PDB 4to4 Chain C

Receptor sequence

>4to4C (length=481) Species: 9606 (Homo sapiens) [Search protein sequence]

DTMKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASH
NRFEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCRNLGHGP
FSHMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPE
EDICFIKEQIVGPLELWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFAR
DCHHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNS
LHRRAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEA
YTKLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKI
KREDYESLPKEVASAKPKVLLDVKLKAEDFIVDVINMDYGMQEKNPIDHV
SFYCKTAPNRAIRITKNQVSQLLPEKFAEQLIRVYCKKVDRKSLYAARQY
FVQWCADRNFTKPQDGDVIAPLITPQKKEWN

3D structure

PDB

4to4 Structural basis of cellular dNTP regulation by SAMHD1.

Chain

Resolution

2.1 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

3.1.5.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	DGT	C	V156 F157 I325 R372 H376 K377	V44 F45 I207 R254 H258 K259
BS02	GTP	C	K116 V117 I118 D137 R145	K4 V5 I6 D25 R33
BS03	GTP	C	Y155 V156 V378 R451	Y43 V44 V260 R333
BS04	DGT	C	R333 R352 K354 N358 K523	R215 R234 K236 N240 K405
BS05	DCP	C	L150 R164 R206 H215 H233 K312 Y315 D319 R366 Y374	L38 R52 R94 H103 H121 K194 Y197 D201 R248 Y256
BS06	DGT	C	V117 N119	V5 N7

External links

PDB	RCSB:4to4, PDBe:4to4, PDBj:4to4
PDBsum	4to4
PubMed	25267621
UniProt	Q9Y3Z3\|SAMH1_HUMAN Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (Gene Name=SAMHD1)

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