Structure of PDB 4to0 Chain C

Receptor sequence

>4to0C (length=481) Species: 9606 (Homo sapiens) [Search protein sequence]

DTMKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASH
NRFEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCRNLGHGP
FSHMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPE
EDICFIKEQIVGPLDSLWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFA
RDCHHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRN
SLHRRAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDME
AYTKLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIK
IKREDYESLPKEVASAKPKVLLDVKLKAEDFIVDVINMDYGMQEKNPIDH
VSFYCKTAPNRAIRITKNQVSQLLPEKFAEQLIRVYCKKVDRKSLYAARQ
YFVQWCADRNFTKPQDGDVIAPLITPQKKEW

3D structure

PDB

4to0 Structural basis of cellular dNTP regulation by SAMHD1.

Chain

Resolution

2.3 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

3.1.5.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	DTP	C	V156 F157 R372 H376	V44 F45 R255 H259
BS02	DTP	C	V117 N119	V5 N7
BS03	GTP	C	K116 V117 I118 D137 R145	K4 V5 I6 D25 R33
BS04	DTP	C	R333 R352 K354 N358 K523	R216 R235 K237 N241 K406
BS05	DCP	C	L150 R164 R206 H210 H215 H233 D311 K312 Y315 D319 R366 Y374	L38 R52 R94 H98 H103 H121 D194 K195 Y198 D202 R249 Y257
BS06	GTP	C	Y155 V156 V378 R451	Y43 V44 V261 R334

External links

PDB	RCSB:4to0, PDBe:4to0, PDBj:4to0
PDBsum	4to0
PubMed	25267621
UniProt	Q9Y3Z3\|SAMH1_HUMAN Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (Gene Name=SAMHD1)

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