Structure of PDB 4tlx Chain C

Receptor sequence

>4tlxC (length=415) Species: 345341 (Kutzneria sp. 744) [Search protein sequence]

PTHDVVGVGFGPANLSLAVALEESPAALTSAFFERRASISWHQGMLLPAA
KMQVSFLKDLATFRNPASRFSFVSFLHERGRLVRFANNHDFFPTRREFHD
YLEWAESKLAHEVSYDSEVTAIRPGPGRPVDSVLVDVSTPEATRTVEARN
IVISTGLVPRMPAGVQSDEFVWHSSRFLDHFRDRDPRSLRRVAVAGGGQS
AAEIVRFLHDNRPDTVVHAIMPSYGYVVADNTPFANQIFDPAAVDDYFDG
SKQAKDAFWRYHRNTNYSVVDDEVIRDLYRRGYDDEVAGAPRLNFVNLAH
VVGAKRIADDTRVTVYSMAREESYDLDVDVLVCATGYDPMDPGDLLGELA
EHCVQDAEGRWQVDRDYRMVTTPDLRCGIYLQGGTEHTHGLSSSLLSNLA
TRSGEIVSSIERRKS

3D structure

PDB

4tlx Crystallographic Evidence of Drastic Conformational Changes in the Active Site of a Flavin-Dependent N-Hydroxylase.

Chain

Resolution

2.23 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

1.14.13.59: L-lysine N(6)-monooxygenase (NADPH).

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	FDA	C	G18 G20 P21 A22 E43 R44 W50 H51 M61 Q62 V128 T164 G165 Y346 S403 L404 L405	G9 G11 P12 A13 E34 R35 W41 H42 M52 Q53 V119 T155 G156 Y337 S394 L395 L396
BS02	NAP	C	K60 Q62 R104 G205 G206 G207 Q208 S209 E212 P231 N275 S277 H309 V310 A343 T344	K51 Q53 R95 G196 G197 G198 Q199 S200 E203 P222 N266 S268 H300 V301 A334 T335
BS03	ORN	C	Q62 V63 K67 N245 F248 N275 S406	Q53 V54 K58 N236 F239 N266 S397

Gene Ontology

	Molecular Function
GO:0000166	nucleotide binding
GO:0004497	monooxygenase activity
GO:0047091	L-lysine 6-monooxygenase (NADPH) activity

	Biological Process
GO:0009058	biosynthetic process

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:4tlx, PDBe:4tlx, PDBj:4tlx
PDBsum	4tlx
PubMed	25184411
UniProt	A8CF85

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